輸血後蕁麻疹発症前の末梢血一般検査所見  [in Japanese] FINDINGS OF BLOOD EXAMINATIONS BEFORE POSTTRANSFUSION URTICARIA  [in Japanese]

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Abstract

【目的】輸血後蕁麻疹は免疫抑制時期には出現しにくいと予想できるが,経験上は骨髄抑制時期でも出現する.輸血後蕁麻疹の予測可能か,あるいは何らかの蕁麻疹出現のメカニズムを検討するため,蕁麻疹が出現した患者の輸血前末梢血検査を後方視的に調査した.【方法】2010年1月から2011年1月まで,広島大学病院・小児科で複数回同種輸血を受け,蕁麻疹を生じた場合と生じなかった場合がみられた症例を対象とした.【結果】末梢血白血球数,特に好塩基球は輸血後蕁麻疹が出現する群で有意に低値だった.血液生化学検査において,AST, ALT, CRP値に両群間で差はなかった.【考察】骨髄抑制による免疫抑制状態なので蕁麻疹は出現しにくいという事実はなく,むしろ白血球減少時の方が,蕁麻疹発症の注意が必要である.

Background: Although the occurrence of posttransfusion urticaria in the immunosuppressive period is believed to be rare, from our experiences, this disease develops regardless of the immune status of the patients. Therefore, we performed a retrospective study to determine whether posttransfusion urticaria develops during the period of bone marrow suppression. Methods: This study included 20 patients who developed urticaria as a complication of blood transfusion from January 2010 to January 2011 at the Department of Pediatrics, Hiroshima University Hospital. We retrospectively analyzed the patients' the blood examination data obtained before blood transfusion to elucidate the mechanism underlying posttransfusion urticaria. Results: White blood cell counts were low before the patients developed urticaria; particularly, neutrophil counts were significantly low. Furthermore, the monocyte, eosinophil, and basophil counts were significantly lower before the development of urticaria. Discussion: Urticaria tends to develop in a condition of neutropenia. Thus, care must be taken to prevent the development of this disease during the neutropenia period.

Journal

  • Japanese Journal of Allergology

    Japanese Journal of Allergology 61(8), 1086-1091, 2012

    Japanese Society of Allergology

References:  20

Codes

  • NII Article ID (NAID)
    110009495640
  • NII NACSIS-CAT ID (NCID)
    AN00012583
  • Text Lang
    JPN
  • Article Type
    ART
  • ISSN
    0021-4884
  • NDL Article ID
    023977736
  • NDL Call No.
    Z19-32
  • Data Source
    CJP  NDL  NII-ELS  J-STAGE 
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