書誌事項
- タイトル別名
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- Effect of vitamin E isoforms on glucose tolerance in mice fed a high-fat diet
- ビタミン E ドウゾクタイ ガ コウシボウショク ユウドウセイ ヒマン マウス ノ タイトウノウ ニ オヨボス エイキョウ
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We investigated the effect of vitamin E isoforms on the glucose tolerance in high-fat-induced obese mice. Eighteen male C57BL/6J mice aged six weeks were divided into three groups and fed a high-fat diet without vitamin E (HF), HF supplemented with 0.1% α-tocopherol (α-Toc) or HF supplemented with 0.1% γ-tocotrienol (γ-T3) for ten weeks. Oral glucose tolerance and insulin tolerance were tested after nine weeks of experimental diet feeding. Although growth rate and food intake were not significantly different among the three groups, addition of γ-T3, but not α-Toc, improved glucose tolerance and insulin sensitivity induced by the high-fat diet in obese mice. Fasting insulin levels in the γ-T3 group were lower than those in other high-fat groups, and the level of insulin secretion following glucose loading was significantly higher in the γ-T3 group than in the HF group. Histological findings showed that islets of the γ-T3 group were sufficiently active to secrete insulin in spite of high-fat feeding. These results suggested that γ-T3, but not α-Toc, protected islets against lipotoxicity and could be effective in treating type 2 diabetes.
収録刊行物
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- ビタミン
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ビタミン 86 (12), 671-677, 2012
公益社団法人 日本ビタミン学会
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詳細情報 詳細情報について
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- CRID
- 1390282680678566912
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- NII論文ID
- 110009562444
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- NII書誌ID
- AN00207833
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- ISSN
- 2424080X
- 0006386X
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- NDL書誌ID
- 024186139
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可