A CASE OF ATOPIC DERMATITIS IN INFANT TREATED WITH CHINESE HERBAL MEDICINES AND NSAIDs OINTMENT, ACCOMPANIED BY WEIGHT LOSS, ELECTROLYTE DISTURBANCE AND HYPOPROTEINEMIA

DOI Web Site 12 References
  • Yasutomi Motoko
    Department of Pediatrics, Faculty of Medical Sciences, University of Fukui
  • Okazaki Shintaro
    Department of Pediatrics, Faculty of Medical Sciences, University of Fukui
  • Kawakita Akiko
    Department of Pediatrics, Faculty of Medical Sciences, University of Fukui
  • Hayashi Hisako
    Department of Pediatrics, Faculty of Medical Sciences, University of Fukui
  • Murai Hiroki
    Department of Pediatrics, Faculty of Medical Sciences, University of Fukui
  • Mayumi Mitsufumi
    Department of Pediatrics, Faculty of Medical Sciences, University of Fukui
  • Wada Taizo
    Department of Pediatrics, School of Medicine Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University
  • Ohshima Yusei
    Department of Pediatrics, Faculty of Medical Sciences, University of Fukui

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Other Title
  • 漢方薬と非ステロイド系消炎鎮痛外用剤による治療で体重減少,電解質異常,低蛋白血症をきたしたアトピー性皮膚炎の1乳児例
  • 症例報告 漢方薬と非ステロイド系消炎鎮痛外用剤による治療で体重減少,電解質異常,低蛋白血症をきたしたアトピー性皮膚炎の1乳児例
  • ショウレイ ホウコク カンポウヤク ト ヒステロイドケイ ショウエン チンツウ ガイヨウザイ ニ ヨル チリョウ デ タイジュウ ゲンショウ,デンカイシツ イジョウ,テイタンパク ケツショウ オ キタシタ アトピーセイ ヒフエン ノ 1 ニュウジレイ

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Abstract

We report here a 4-month-old girl with atopic dermatitis accompanied by weight loss, electrolyte disturbance, hypoproteinemia and hypogammaglobulinemia. She has suffered from eczema since one-month of age. Although she was treated with Chinese herbal medicines, including Syosaikotokakikyosekko, Tokishigyakukagoshuyushokyoto and Jumihaidokuto and ibuprofen ointment since three-month of age, she was referred to our hospital due to deteriorated eczema, severe diarrhea and failure to thrive. Laboratory examination revealed hyponatremia, hyperpotassemia, hypoproteinemia, hypogammaglobulinemia and elevated levels of serum IL-18, TARC and fecal EDN. Drug-induced lymphocyte stimulation tests were positive for the prescribed Chinese herbal medicines. Discontinuation of these medicines and application of steroid ointments improved loose bowels and skin lesions as well as laboratory data. It is suggested that the application of inadequate ointment and Chinese herbal medicines exaggerated inflammation in the skin and the intestinal mucosa leading to electrolyte disturbance, hypoproteinemia and hypogammaglobulinemia. Chinese herbal medicines are depicted as an additional therapy in Japanese guideline for atopic dermatitis, whereas their indication to infants with atopic dermatitis should be carefully assessed.

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