Group3LEAペプチドのタンパク質凝集抑制メカニズムに関する実験的研究

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  • Experimental Study on the Mechanism Underlying the Anti-aggregation Function of a Group3LEA Peptide
  • Group3LEA ペプチド ノ タンパクシツ ギョウシュウ ヨクセイ メカニズム ニ カンスル ジッケンテキ ケンキュウ

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We show that a short model peptide which has two tandem repeats of the 11-mer motif of a group3 late embryogenesis abundant protein protects proteins against aggregation by desiccation stress. Next, we measure the dissociation constant between the LEA model peptide and its partner protein (lysozyme and HybD) using quartz crystal microbalance (QCM) method. Similar experiments are performed for a native LEA protein from the anhydrobiotic nematode A. avenae. On the basis of these results, the mechanism of the anti-aggregation function of the LEA peptide is discussed.

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