Effects of Low-intensity Pulsed Ultrasound on Bone Formation Induced by Recombinant Human BMP-2 in Adult Rats
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- YAMAJI Kozo
- Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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- SHIODE Shintaro
- Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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- ODAJIMA Tomoomi
- Department of Peridontology and Endodontology, Division of Oral Health Science, Hokkaido University Graduate School of Dental Medicine
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- NISHITANI Yoshihiro
- Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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- IZAWA Shunji
- Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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- TANAKA Kumiko
- Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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- OHARA Naoko
- Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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- NISHIMURA Maiko
- Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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- YOKOYAMA Akihito
- Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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- SUGAYA Tsutomu
- Department of Peridontology and Endodontology, Division of Oral Health Science, Hokkaido University Graduate School of Dental Medicine
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- KAWANAMI Masamitsu
- Department of Peridontology and Endodontology, Division of Oral Health Science, Hokkaido University Graduate School of Dental Medicine
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- YOSHIYAMA Masahiro
- Department of Operative Dentistry, Field of Study of Biofunctional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Bibliographic Information
- Other Title
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- リコンビナントヒトBMP-2を成体ラットに移植した場合の骨形成に対する低出力超音波パルスの影響
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Abstract
Purpose: The purpose of this study was to evaluate the effects of low-intensity pulsed ultrasound (LIPUS) on bone formation induced by polylactate-polyglycolate-copolymer/gelatin sponge complexes (PGS) containing recombinant human bone morphogenetic protein-2 (rhBMP-2) at palatal subperiosteal sites (n=24) in 15-week-old male Wistar rats. Methods: RhBMP-2/PGS (1.0 μg/μl) was implanted into the palatal subperiosteal site and treated with LIPUS (1.0 MHz, 240 mW, 5 min) every 3 days (LI-BMP group) or without LIPUS (BMP group). In addition, rhBMP-2/PGS (1.0 μg/μl) was not implanted and rats were treated with LIPUS (LI group) or were not treated with LIPUS (Cont group). Animals were euthanized 3 weeks after surgery. Results: Thickness of new bone in LI-BMP and BMP groups was significantly higher when compared with LI and Cont groups (p<0.05). There were no significant differences in thickness of new bone between LI-BMP and BMP groups (p>0.05). Newly formed bone in the BMP group was continuous with the original bone. On the other hand, newly formed bone was largely integrated with the original bone in the LI-BMP group. Conclusion: These results suggest that LIPUS has the ability to enhance maturation of bone induced by rhBMP-2 in the case of palatal subperiosteal implantation in adult rats.
Journal
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- The Japanese Journal of Conservative Dentistry
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The Japanese Journal of Conservative Dentistry 56 (4), 318-324, 2013
The Japanese Society of Conservative Dentistry
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Details 詳細情報について
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- CRID
- 1390001205521668224
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- NII Article ID
- 110009674441
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- ISSN
- 21880808
- 03872343
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed