Development of Oral and Extra-Oral Endosseous Craniofacial Implants by Using a Mesh Structure for Connective Tissue Attachment

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  • 三田 敦
    Medical and Dental Device Technology Incubation Center, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
  • 八木原 淳史
    Medical and Dental Device Technology Incubation Center, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
  • 王 巍
    Medical and Dental Device Technology Incubation Center, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
  • 髙久田 和夫
    Medical and Dental Device Technology Incubation Center, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University

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Connective tissue attachment to a mesh structure incorporated on the surface of oral implants and extra-oral endosseous craniofacial implants (EOECI) was investigated. Two types of implants were prepared: TI and TI-Mesh. TI was composed of an upper and a lower component, both comprised of a titanium cylinder, which could be connected using a titanium screw. The composition of the TIMesh was similar, but the lower cylinder had a lateral groove that was covered with a titanium mesh. In animal experiments performed using rat calvaria, the lower component was first implanted and was left submerged for 3 weeks, then the upper component was mounted percutaneously. After an additional 2 weeks, each implant and the surrounding tissues were harvested and evaluated. Histological observations revealed collagen fibers originating from surrounding hypodermal tissues anchored to the mesh structures of the TI-Mesh whereas no such collagen fibers were observed around TI. Significantly greater values of the attachment strength, the thickness of the dermal tissue, the thickness of hypodermal tissue, and the attachment lengths were observed in TI-Mesh than those of TI. Thus connective tissue attachment with collagen fibers anchored to the mesh was achieved by incorporating mesh structures into the percutaneously placed implants.

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