4 アスヒカズラ(Lycopodium complanatum)由来新規アルカロイドの構造(口頭発表の部)

• 石内 勘一郎

  北大院薬

• 久保田 高明

  北大院薬

• 林 茂樹

  基盤研・薬植セ

• 柴田 敏郎

  基盤研・薬植セ

• 小林 淳一

  北大院薬

書誌事項

タイトル別名

• Structures of New Alkaloids from Lycopodium complanatum

抄録

Club moss (Lycopodiaceae) is known to be a rich source of Lycopodium alkaloids possessing unique heterocyclic ring systems such as C_<16>N, C_<16>N_2, and C_<27>N_3, which have attracted great interest from biogenetic, synthetic, and biological points of view. In our continuing efforts to find new Lycopodium alkaloids, lycopladine H (1), lyconadins C-E (2-4), lycoplaidines F-G (5-6), and complanadine E (7) were isolated from Lycopodium domplanatum. The structures for 1-7 were elucidated on the basis of spectral data. Lycopladine H (1) is an unprecedented C_<16>N-type Lycopodium alkaloid possessing a novel fused-tetracyclic ring system consisting of an azocane ring fused to a [2,2,2,]-bicyclooctane ring and 3-piperidinone ring, Lyconadin C (2) is a new tetracyclic Lycopodium alkaloid consisting of cyclohexane, cycloheptane, pyperidine, and pyridone rings. Lyconadin C (2) might be a biosynthetic precursor of lyconadin A. Lyconadins D (3) and E (4) are the first fastigiatine-type alkaloids isolated from Lycopodium complanatum. Lycopladine F (5) is a rare C_<16>N_2-type Lycopodium alkaloid possessing an amino acid residue (C_4N), while lycopladine G (6) is a 17-keto and 20-methylester form of lycopladine F (5). Complanadine E (7) is a new dimeric Lycopodium alkaloid consisting of two C_<16>N_2-type skeletons, which corresponds to 1,2,3,4,5,N-1-hexahydro complanadine A.

収録刊行物

• 天然有機化合物討論会講演要旨集

  天然有機化合物討論会講演要旨集 51 (0), 19-24, 2009

  天然有機化合物討論会実行委員会

詳細情報

• CRID: 1390282681054978176
• NII論文ID: 110009757611
• DOI: 10.24496/tennenyuki.51.0_19
• ISSN: 24331856
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可