P-38 海綿由来の新規マンザミンアルカロイドzamamidine A～Cの構造と生物活性(ポスター発表の部)

• 高橋 洋平

  北大院薬

• 山田 美香

  北大院薬

• 久保田 高明

  北大院薬

• 石山 亜紀

  北里大生命研

• 乙黒 一彦

  北里大生命研

• 山田 陽城

  北里大生命研

• 大村 智

  北里大生命研

• 小林 淳一

  北大院薬

書誌事項

タイトル別名

• Structures and Bioactivities of Zamamidines A-C, New Manzamine Alkaloids from Marine Sponges

抄録

Manzamine alkdloids are well known to be a group of marine natural products, which have a β-carboline moiety and a unique heterocyclic ring system. Since manzamine A had been isolated from a marine sponge Haliclona sp. in 1986, approximately 100 manzamine alkdloids containing biogenetic precursors have been idolated so far. A great number of studies on them, such as isolation and structural analysis, biosynthesis, and total synthesis, have been actively performed due to their intriguing structures and intersting biological activities. We have also isolated s seris of manzamine alkaloids from several genera and their structures have been elucidated by means of NMR spectra, chemical correlations, X-ray crystallography, and CD spectra. During our continuous search for structurally interesting metabolites from marine sponges, new manzamine alkdloids, zamamidines A-C (1-3), have been isolated, and their structures were elucidated by spectroscopic data. 1-3 are new manzamine alkdloids possessing a second β-carboline ring via an ethylene chain at N-2 of manzamine H, 1,2,3,4-tetrahydromanzamine B, and manzamine D, respectively. Since no manzamine alkdloids possessing any side chain at N-2 other than a methyl group have been reported to date, 1〜3 are the first examples of it. Zamamidines A-C (1-3) showed inhibitory activities against Plasmodium falciparum (Kl strain) and Tripanosoma brucei brucei (GUTat 3.1) in vitro.

収録刊行物

• 天然有機化合物討論会講演要旨集

  天然有機化合物討論会講演要旨集 51 (0), 581-586, 2009

  天然有機化合物討論会実行委員会

詳細情報

• CRID: 1390001206077894912
• NII論文ID: 110009757705
• DOI: 10.24496/tennenyuki.51.0_581
• ISSN: 24331856
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可