P-60 インドネシア産海綿由来furospinosulin-1の低酸素環境特異的がん細胞増殖阻害活性(ポスター発表の部)

• 荒井 雅吉

  阪大院薬

• 河内 崇志

  阪大院薬

• 古徳 直之

  阪大院薬

• 住井 裕司

  阪大院薬

• 藤岡 真一

  阪大院薬

• 小林 資正

  阪大院薬

書誌事項

タイトル別名

• Hypoxia selective cytotoxicity of furospinosulin-1 from Indonesian marine sponge

抄録

Hypoxic enrvironment on tumor is now recognized to be an important factor for tumor growth, angiogenesis, metastasis and response to chemotherapy and irradiation. Then, the compounds, which exhibit growh inhibitory activity against tumor cells under hypoxic environment slelctively, are expected to be promising nes lead for anti-cancer drugs. Furthermore it is an important to find new responsible molecules for the adaptation of hypoxia in tumor cells through analysis of action-mechanism of the compound, because the adaption of hypoxia in tumor cells is not completely clarified. In the course of our search for hypoxia-selective growth inhibitors, a furanosesterterpene, furospinosulin-1 (1), was isolates from an Indonesia marine sponge of Suberea sp. The compound 1 showed selective growth inhibitory activity against human prostate cancer cells DU145 under 1% or low oxygen atmosphere dose-dependently, while the compound 1 did not inhibit production of Hypoxia Inducible Factor-1α (HIF-1α), which is considered to be a major transcription factor to adapt hypoxic environment in tumor. Moreover, furospinosulin-1 (1) suppressed tumor growth in the mice s.c.-inoculated mouse sarcoma S180 cells. Then, the Pathway-Specific Oligo GEArray analysis was carried out to elucidate action-mechanism of compound 1. The data suggested hat furospinosulin-1 (1) might inhibit signaling of insulin growth factor 1 receptor (IGF-1R) via suppression of insulin-like growth factor-2 (IGF-2).

収録刊行物

• 天然有機化合物討論会講演要旨集

  天然有機化合物討論会講演要旨集 51 (0), 647-652, 2009

  天然有機化合物討論会実行委員会

詳細情報

• CRID: 1390001206077864064
• NII論文ID: 110009757716
• DOI: 10.24496/tennenyuki.51.0_647
• ISSN: 24331856
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可