Histopathological characteristics of laterally spreading tumor (LST) type early colorectal cancer.
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- Takasugi Kaori
- Departments of Pathology and Bioscience, Hirosaki University Graduate School of Medicine Department of Gastroenterology, Hirosaki University Graduates School of Medicine
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- Morohashi Satoko
- Departments of Pathology and Bioscience, Hirosaki University Graduate School of Medicine
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- Haga Toshihiro
- Departments of Pathology and Bioscience, Hirosaki University Graduate School of Medicine Department of Gastroenterology, Hirosaki University Graduates School of Medicine
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- Toba Takahito
- Departments of Pathology and Bioscience, Hirosaki University Graduate School of Medicine
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- Seino Hiroko
- Departments of Pathology and Bioscience, Hirosaki University Graduate School of Medicine
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- Wu Yunyan
- Departments of Pathology and Bioscience, Hirosaki University Graduate School of Medicine
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- Suzuki Takahiro
- Departments of Pathology and Bioscience, Hirosaki University Graduate School of Medicine
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- Hanabata Norihiro
- Department of Gastroenterology, Hirosaki University Graduates School of Medicine
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- Sasaki Yoshihiro
- Department of Medical Informatics, Hirosaki University Graduates School of Medicine
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- Fukuda Shinsaku
- Department of Gastroenterology, Hirosaki University Graduates School of Medicine
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- Kijima Hiroshi
- Departments of Pathology and Bioscience, Hirosaki University Graduate School of Medicine
Bibliographic Information
- Other Title
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- 側方伸展型発育を示す早期大腸癌の組織学的特徴
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Abstract
Recently, laterally spreading tumor (LST) of early colorectal carcinoma has been treated by endoscopic submucosal dissection (ESD) more frequently. Many cases of early colorectal carcinomas are diagnosed as well differentiated adenocarcinomas, but histological and/or immunohistorogical heterogeneity is often seen in LSTs. In this study, we analyzed morphological characteristics of 61 lesions of LST-type early colorectal carcinoma by using histolosical and immunohistochemical procedures. Presence of high grade atypia components was significantly correlated with depth of submucosal invasion (P=0.0102), and these were predominantly located to the invasive front (deep part) of the submucosal carcinoma. Allred scores of p53 and Ki-67 labeling indices were increased in the component of high grade atypia regardless of depth of invasion. Expressions of CDX2 and CD10 were significantly upregulated in a depth-of-invasion dependent manner, and these tended to be highly expressed in the high grade atypias. In conclusion, the present study indicates that the majority of LST is histologically heterogeneic. The component of high grade atypia of LST upregulates cell proliferation, which may leed to increase the malignant potential of LST for invading the submucosa.
Journal
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- Hirosaki Medical Journal
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Hirosaki Medical Journal 64 (2-4), 158-169, 2014
Hirosaki University Graduate School of Medicine,Hirosaki Medical Society
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Details 詳細情報について
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- CRID
- 1390570000438541312
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- NII Article ID
- 110009758622
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- NII Book ID
- AN00211444
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- ISSN
- 24344656
- 04391721
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- HANDLE
- 10129/5199
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- NDL BIB ID
- 025325987
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed