書誌事項
- タイトル別名
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- S022034 Study on the mechanism of mesh-like structure formation by endothelial cells with modified glycans
抄録
It has been reported that glycans play pivotal roles in biomechanical responses of cells. To reveal the roles of glycans in mechanical response of endothelial cells, we observed morphological changes of a murine vascular endothelial cell line F-2 treated with a drug DG, which modifies protein glycosylation. When a confluent cell monolayer was treated with DG in static culture, it formed mesh-like structure in 48 hours. To reveal the reason for the mesh-like structure formation, we measured adhesion strength between the cells and that between the cell and the substrate with laboratory-made testers and found that the mesh-like structure formation was accompanied by an increase in the intercellular adhesion strength and a decrease in the cell-substrate adhesion strength. These changes may facilitate local aggregation of cells in a cell monolayer and thus cause the mesh-like structure.
収録刊行物
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- 年次大会
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年次大会 2011 (0), _S022034-1-_S022034-4, 2011
一般社団法人 日本機械学会
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詳細情報 詳細情報について
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- CRID
- 1390001205840056576
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- NII論文ID
- 110009759810
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- ISSN
- 24242667
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可