高尿酸血症・痛風の危険選択  [in Japanese] Risk Selection of Hyperuricemia and Gout  [in Japanese]

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Author(s)

    • 佐藤 和夫 Sato Kazuo
    • チューリッヒ・ライフ・インシュアランス・カンパニー・リミテッド Zurich Life Insurance Company Ltd.

Abstract

尿酸はプリン体の酸化代謝物である。高尿酸血症は血清尿酸値が7.0 mg/dLを超えた状態と定義されており,この値を超えると尿酸が血液飽和状態となり結晶化や組織への沈着が起こる。高尿酸血症でよく知られた徴候は痛風である。高尿酸血症・痛風は30歳〜40歳代の男性に最も多く発症する。高尿酸血症・痛風は慢性腎臓病や高血圧と深く関連する。さらに,高尿酸血症は心血管障害と関係するという報告があるが,否定的な研究結果もあり,高尿酸血症は心血管障害の独立危険因子か否か見解の一致をみていない。本稿では高尿酸血症や痛風の告知があった際,どのように査定評価すべきか検討した。

Uric acid (UA) is the final oxidation product of purine metabolism. Hyperuricemia is defined as a serum UA level greater than 7.0 mg/dL: above this concentration, UA is considered supersaturated in the blood, and is prone to crystallization and subsequent tissue deposition. The best-known medical manifestation of hyperuricemia is gout, a disorder that is common in men in their thirties and forties. Gout or acute gouty arthritis is caused by the deposition of UA crystals in the joints and surrounding soft tissue. Hyperuricemia or gout was reported to be closely associated with hypertension and chronic kidney disease. Furthermore, hyperuricemia is believed to be frequently associated with cardio vascular diseases (CVD); however, the data regarding whether hyperuricemia is an independent risk factor for CVD have been controversial. In this paper, we review the relevant literature and assess the risk of hyperuricemia and gout from a practical standpoint.

Journal

  • The journal of the Association of Life Insurance Medicine of Japan

    The journal of the Association of Life Insurance Medicine of Japan 112(2), 132-149, 2014-06

    The Association of Insuramce Medicine of Japan

Codes

  • NII Article ID (NAID)
    110009830669
  • NII NACSIS-CAT ID (NCID)
    AN00197853
  • Text Lang
    JPN
  • ISSN
    0301-262X
  • NDL Article ID
    025631590
  • NDL Call No.
    Z19-675
  • Data Source
    NDL  NII-ELS 
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