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- Murakami Manabu
- Department of Pharmacology, Hirosaki University Graduate School of Medicine
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- Nemoto Takayuki
- Department of Pharmacology, Graduate School of Medicine, University of Miyazaki
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- Niwa Hidetoshi
- Department of Anesthesiology, Hirosaki University Graduate School of Medicine
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- Kushikata Tetsuya
- Department of Anesthesiology, Hirosaki University Graduate School of Medicine
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- Ono Kyouichi
- Department of Cellphysiology, Akita University School of Medicine
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- Watanabe Hiroyuki
- Department of Internal Medicine Division of Cardiovascular and Respiratory Medicine, Akita University School of Medicine
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- Hirota Kazuyoshi
- Department of Anesthesiology, Hirosaki University Graduate School of Medicine
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- Ohba Takayoshi
- Department of Cellphysiology, Akita University School of Medicine
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Abstract
Aims: The purpose of the current study was to evaluate the significance of the endothelin system in catecholamine release and synthesis in the adrenal gland.<br> Main Methods: Primary cultures of isolated bovine adrenal medullary cells were prepared. Gene expression, intracellular calcium changes, epinephrine release, and other factors were investigated.<br> Key findings: Expression of endothelin receptors in the rat adrenal gland was confirmed. Intravenous infusion of endothelin-1 (1.0 nmol) increased blood pressure (systolic and diastolic). Endothelin-1 stimulated intracellular calcium changes, resulting in increased nuclear factor of T cell (NFAT) activity and epinephrine release from cultured adrenal medullary cells. Furthermore, endothelin-1 increased catecholamine synthesis and caused hypertrophic changes in the cell size.<br> Significance: Our findings indicate involvement of the endothelin system in the sympathetic regulation of the adrenal medulla.
Journal
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- Hirosaki Medical Journal
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Hirosaki Medical Journal 65 (2-4), 218-226, 2014
Hirosaki University Graduate School of Medicine,Hirosaki Medical Society
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Details 詳細情報について
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- CRID
- 1390006895527186176
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- NII Article ID
- 110009838284
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- NII Book ID
- AN00211444
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- ISSN
- 24344656
- 04391721
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- HANDLE
- 10129/5430
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- NDL BIB ID
- 025848701
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed