Efficacy of Electrochemotherapy with Bleomycin to the Murine Osteosarcoma Model

機関リポジトリ

書誌事項

タイトル別名
  • 骨肉腫の動物モデルにBleomycinを用いたElectrochemotherapyの有効性

この論文をさがす

抄録

論文(Article)

Background : Electrochemotherapy is an unique treatment to enhance the drug permeability of tumor cells. It is believed that osteosarcoma lacks the membrane proteins, which constitutes an obstacle in achieving drug transport for chemotherapy. We performed the electrochemotherapy with bleomycin to evaluate the efficacy of the treatment in an animal model of osteosarcoma. The tumor response, tissue concentration of bleomycin and histology were analyzed. Materials and Methods : SCID mice that had been subcutaneously implanted with osteosarcoma cells were subjected to electroporation, bleomycin, both or with no treatment as a control. Results : Cells cycle arrest and growth inhibiton were observed in the murine osteosarcoma only in the electroporation with bleomycin plus group. The tissue concentrations of bleomycin were high in the bleomycin plus group and low in the bleomycin alone group. Conclusion : The present study indicates that electrochemotherapy with bleomycin may be an effective treatment for osteosarcoma

収録刊行物

詳細情報 詳細情報について

問題の指摘

ページトップへ