ビタミンD欠乏症の発症に関する遺伝子多型(<特集>第66回大会シンポジウム「栄養と臨床におけるビタミンの遺伝子多型に基づいたテーラーメイド摂取の有用性」)  [in Japanese] Gene polymorphisms associated with vitamin D deficiency  [in Japanese]

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Author(s)

    • 北中 幸子 Kitanaka Sachiko
    • 東京大学大学院医学系研究科小児医学講座 Dept. of Pediatrics, Graduate School of Medicine, The University of Tokyo

Abstract

Deficiency of vitamin D due to an insufficient intake of vitamin D and lack of sunshine exposure in childhood leads to diseases caused by vitamin D deficiency such as hypocalcemic seizures, rickets, infantile convulsion, bowlegs, short stature, and developmental motor skills disorder. Recently, the number of patients with vitamin D deficiency has been increased with changes in environmental factors. However, there are many cases of vitamin D deficiency which cannot be explained by the environmental factors alone. We have analyzed the genetic predisposition for the onset of vitamin D deficiency and have found differences in the polymorphisms or haplotypes of VDR, GC, and NADSYN1 genes in patients with vitamin D deficiency. Thus, genetic factors may predispose to vitamin D deficiency to some extent. Therefore, it has been thought that further examination is needed for establishment of tailor-made intake of vitamin D in the future.

Journal

  • VITAMINS

    VITAMINS 89(2), 72-74, 2015

    THE VITAMIN SOCIETY OF JAPAN

Codes

  • NII Article ID (NAID)
    110009917754
  • NII NACSIS-CAT ID (NCID)
    AN00207833
  • Text Lang
    JPN
  • ISSN
    0006-386X
  • NDL Article ID
    026183243
  • NDL Call No.
    Z19-36
  • Data Source
    NDL  NII-ELS  J-STAGE 
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