ビタミンD欠乏症の発症に関する遺伝子多型(<特集>第66回大会シンポジウム「栄養と臨床におけるビタミンの遺伝子多型に基づいたテーラーメイド摂取の有用性」) [in Japanese] Gene polymorphisms associated with vitamin D deficiency [in Japanese]
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Deficiency of vitamin D due to an insufficient intake of vitamin D and lack of sunshine exposure in childhood leads to diseases caused by vitamin D deficiency such as hypocalcemic seizures, rickets, infantile convulsion, bowlegs, short stature, and developmental motor skills disorder. Recently, the number of patients with vitamin D deficiency has been increased with changes in environmental factors. However, there are many cases of vitamin D deficiency which cannot be explained by the environmental factors alone. We have analyzed the genetic predisposition for the onset of vitamin D deficiency and have found differences in the polymorphisms or haplotypes of VDR, GC, and NADSYN1 genes in patients with vitamin D deficiency. Thus, genetic factors may predispose to vitamin D deficiency to some extent. Therefore, it has been thought that further examination is needed for establishment of tailor-made intake of vitamin D in the future.
VITAMINS 89(2), 72-74, 2015
THE VITAMIN SOCIETY OF JAPAN