509 せん断流れ場におけるin vitro血栓形成挙動観察(OS5-(2),OS5 オーガナイズドセッション《ライフサポートにおける工学技術》)

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  • 509 Observation of in vitro thrombosis behavior under shear flow field

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In vitro antithrombogenic testing is a useful pre-evaluation for ex vivo test of a continuous flow pump as an artificial heart. In our previous study, we have quantitatively obtained the results that the increasing shear rate prevented the thrombus formation using a double-cylinder type rheometer. However, it is not yet cleared that the thrombosis procedures occurred at between the inner and the outer cylinders. This paper describes that the optical and direct observation of the in vitro thrombosis under shear flow fields. This results showed that the thrombus formation started from the surface of rotating outer cylinder made of glass. Thus, it is considered that in vitro thrombosis closely related to the not only blood coagulability and/or shear rate, but also chemical condition of blood-contacting surface.

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