Oxytocin and the Gastrin-Releasing Peptide System in the Spinal Cord : Implications for Male Sexual Problems (Special issue : proceedings of parvo- and magnocellular symposium in Sendai : creating a new stream of neuroendocrinology) Oxytocin and the Gastrin-Releasing Peptide System in the Spinal Cord: Implications for Male Sexual Problems

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Author(s)

    • SAKAMOTO Hirotaka
    • Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University
    • OTI Takumi
    • Ushimado Marine Institute (UMI), Graduate School of Natural Science and Technology, Okayama University

Abstract

Neural circuits underlying male sexual function comprise several nuclei located in the brain and spinal cord. We have previously demonstrated in rats that the gastrin-releasing peptide (GRP) system influences spinal centers promoting penile reflexes. Moreover, a group of oxytocin (OXT) neurons, situated in the parvocellular part of the paraventricular nucleus of the hypothalamus, project into the spinal cord and control penile reflexes. Therefore, it has been hypothesized that OXT is transported by long descending paraventriculospinal pathways and activates proerectile spinal centers. Consequently, we have shown that in rats, axonal distribution of OXT in the lumbar spinal cord exhibits a male-dominant sexual dimorphism. Furthermore, OXT binding is observed in the spinal GRP neurons. Thus, OXT axons may secrete OXT from spinal axonal terminals and regulate male sexual function via an OXT receptor-mediated mechanism in spinal GRP neurons. Future studies should address the relationship between the hypothalamic OXT and spinal GRP systems. Identification of the male-specific brain-spinal cord neural circuit that regulates male sexual behavior may provide new avenues for therapeutic approaches to masculine reproductive dysfunction, including erectile dysfunction and/or ejaculation disorder.

Journal

  • Interdisciplinary Information Sciences

    Interdisciplinary Information Sciences 21(3), 235-242, 2015

    Graduate School of Information Sciences, Tohoku University

Codes

  • NII Article ID (NAID)
    110009966532
  • NII NACSIS-CAT ID (NCID)
    AA11032627
  • Text Lang
    ENG
  • Article Type
    departmental bulletin paper
  • ISSN
    1340-9050
  • Data Source
    NII-ELS  IR  J-STAGE 
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