Effects of N,N-dimethyldodecylamine-N-oxide on some cellular parameters of rat thymocytes

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著者

    • Ohiwa Yurie Ohiwa Yurie
    • Laboratory of Cellular Signaling, Graduate School of Integrated Arts and Sciences, Tokushima University
    • Yamada Mari Yamada Mari
    • Laboratory of Cellular Signaling, Graduate School of Integrated Arts and Sciences, Tokushima University
    • Sumi Ayaka Sumi Ayaka
    • Laboratory of Cellular Signaling, Graduate School of Integrated Arts and Sciences, Tokushima University
    • Oyama Yasuo Oyama Yasuo
    • Laboratory of Cellular Signaling, Graduate School of Integrated Arts and Sciences, Tokushima University

抄録

N,N-Dimethyldodecylamine-N-oxide (DDAO) is an amphoteric surfactant used in many detergents for kitchens. In this study, the effects of DDAO (10–100 μM) on cell lethality, intracellular Ca2+ level, intracellular Zn2+ level, and cellular content of nonprotein thiol were examined in mammalian cells (rat thymocytes) to further characterize its cytotoxicity. DDAO at the concentration of 100 μM (22.9 mg/L) slightly, but significantly, increased the parameters described above, and it showed no significant effect at the concentrations of 30 μM (6.87 mg/L) or less. Therefore, it is unlikely that DDAO at environmentally-relevant concentrations (< 10–70 ng/L) exerts toxic actions on wild mammals and humans.

収録刊行物

  • 徳島大学総合科学部自然科学研究

    徳島大学総合科学部自然科学研究 29, 1-4, 2015

    徳島大学

各種コード

  • NII論文ID(NAID)
    110010016063
  • NII書誌ID(NCID)
    AN10065859
  • 本文言語コード
    ENG
  • 資料種別
    Departmental Bulletin Paper
  • 雑誌種別
    大学紀要
  • ISSN
    09146385
  • NDL 記事登録ID
    028436027
  • NDL 請求記号
    Z14-1395
  • データ提供元
    NDL  NII-ELS  IR 
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