Cell death process induced by hydrogen peroxide is accelerated by clioquinol in rat thymocytes

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We examined the effect of clioquinol on the process of cell death induced by hydrogen peroxide (H2O2) using a flow cytometric technique with propidium iodide and annexin V-FITC in order to see if clioquinol augments the toxicity caused by oxidative stress. Clioquinol (100 nM) alone did not change the process of spontaneous cell death. However, the agent accelerated the process of cell death induced by 300 μM H2O2. Result indicates that clioquinol augments the cytotoxicity induced by H2O2. Therefore, the use of clioquinol may be inadequate for the treatment of some diseases related to oxidative stress.

収録刊行物

  • 徳島大学総合科学部自然科学研究

    徳島大学総合科学部自然科学研究 29, 31-33, 2015

    徳島大学

各種コード

  • NII論文ID(NAID)
    110010016078
  • NII書誌ID(NCID)
    AN10065859
  • 本文言語コード
    ENG
  • 資料種別
    Departmental Bulletin Paper
  • 雑誌種別
    大学紀要
  • ISSN
    09146385
  • NDL 記事登録ID
    028436072
  • NDL 請求記号
    Z14-1395
  • データ提供元
    NDL  NII-ELS  IR 
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