Synthesis of novel amino acid-type fullerenes and their inhibition activity of HIV reverse transcriptase and HCV RNA polymerase
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Abstract
type:text
We synthesized novel fullerene derivatives with amino, carboxylic, and ethyl ester groups. The HIV reverse transcriptase (HIV-RT) inhibition activities of these derivatives were higher than those of nevirapine, a clinically used HIV-RT inhibitor. However, they were less effective than those of the tricarboxylic derivative previously reported by our group, and the numbers of carboxylic groups did not affect the HIV-RT inhibition activity. Some derivatives have HCV RNA polymerase (HCV-RP) inhibition activities as well. Further optimization of the structure of the fullerene derivatives is required.
identifier:CODEN: KYDZAU
Journal
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- 共立薬科大学雑誌
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共立薬科大学雑誌 1 77-84, 2006-03
共立薬科大学
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Details 詳細情報について
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- CRID
- 1050845762325250688
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- NII Article ID
- 120000801772
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- ISSN
- 18805116
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- Text Lang
- en
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- Article Type
- departmental bulletin paper
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- Data Source
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- IRDB
- CiNii Articles