Ca2+-assisted receptor-driven endocannabinoid release: mechanisms that associate presynaptic and postsynaptic activities

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Abstract

金沢大学大学院医学系研究科機能障害学Endogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. They are released from postsynaptic neurons and cause transient and long-lasting reduction of neurotransmitter release through activation of presynaptic cannabinoid receptors. Endocannabinoid release is induced either by increased postsynaptic Ca2+ levels or by activation of Gq/11-coupled receptors. When these two stimuli coincide, endocannabinoid release is markedly enhanced, which is attributed to the Ca2+ dependency of phospholipase Cβ (PLCβ). This Ca2+-assisted receptor-driven endocannabinoid release is suggested to participate in various forms of synaptic plasticity, including short-term associative plasticity in the cerebellum and spike-timing-dependent long-term depression in the somatosensory cortex. In these forms of plasticity, PLCβ seems to function as a coincident detector of presynaptic and postsynaptic activities. © 2007 Elsevier Ltd. All rights reserved.

Journal

  • Current Opinion in Neurobiology

    Current Opinion in Neurobiology 17(3), 360-365, 2007-06-01

    Elsevier

Codes

  • NII Article ID (NAID)
    120000809396
  • NII NACSIS-CAT ID (NCID)
    AA1082632X
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    0959-4388
  • Data Source
    IR 
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