Freeze-dried platelets promote hepatocyte proliferation in mice Freeze-dried platelets promote hepatocyte proliferation in mice

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In recent years, platelets are reported to promote liver, as well as bone regeneration and dermal wound healing. Platelets are required not only for thrombocytopenia treating but also for regenerative therapy. Platelets cannot be stored beyond three days, therefore, shortage of fresh platelets sometimes occurs. To preserve platelets for a long duration without degrading growth factors, a freeze-dried technique is required. We report here that platelets can be preserved by freeze-drying, using a programmed freezing method to avoid intracellular ice crystal formation. Freeze-dried platelets kept their morphological countenance and response with the agonist of thrombin was well maintained. Freeze-dried platelets stored adenine nucleotides, PDGF, and IGF-1 the same as those of fresh platelets. Freeze dried platelets also preserved their proliferative effect on hepatocytes identical to that of fresh platelets. These results of our study suggest that freeze dried platelets will obviate the storage problem of fresh platelets.

収録刊行物

  • Cryobiology

    Cryobiology 55(3), 255-260, 2007-12

    Elsevier

被引用文献:  3件中 1-3件 を表示

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各種コード

  • NII論文ID(NAID)
    120000835287
  • NII書誌ID(NCID)
    AA11544946
  • 本文言語コード
    ENG
  • 資料種別
    journal article
  • ISSN
    0011-2240
  • データ提供元
    CJP引用  IR 
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