Novel excitatory neuropeptides isolated from a prosobranch gastropod, Thais clavigera : The molluscan counterpart of the annelidan GGNG peptides

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Abstract

The GGNG peptides are excitatory neuropeptides identified from earthworms, leeches and polychaeta. Two structurally related peptides were purified and characterized from a mollusk, Thais clavigera (prosobranch gastropod). The peptides designated as TEP-1 (Thais excitatory peptide-1) (KCSGKWAIHACWGGN-NH2) and TEP-2 (KCYGKWAMHACWGGN-NH2) are pentadecapeptides having one disulfide bond and C-terminal GGN-NH2 structures, which are shared by most GGNG peptides. TEP augmented the motilities of Thais esophagus and penial complex. TEP-like immunoreactivity is distributed in both the neurons of the central nervous system and nerve endings in the penial complex. Thus, the involvement of TEP in the contraction of the digestive and reproductive systems is suggested. Substitution of amino acids in TEP revealed that two tryptophan residues in TEP are important for maintaining bioactivity.

Journal

  • Peptides

    Peptides 27(3), 483-492, 2006-03

    Elsevier

Cited by:  1

Codes

  • NII Article ID (NAID)
    120000878119
  • NII NACSIS-CAT ID (NCID)
    AA10617807
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    0196-9781
  • Data Source
    CJPref  IR 
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