Novel excitatory neuropeptides isolated from a prosobranch gastropod, Thais clavigera : The molluscan counterpart of the annelidan GGNG peptides

• Morishita, Fumihiro

• Minakata, Hiroyuki

• Takeshige, K.

• Furukawa, Yasuo

• Takata, T.

• Matsushima, Osamu

• Mukai, S.T.

• Saleuddin, A.S.M.

• Horiguchi, Toshihiro

抄録

The GGNG peptides are excitatory neuropeptides identified from earthworms, leeches and polychaeta. Two structurally related peptides were purified and characterized from a mollusk, Thais clavigera (prosobranch gastropod). The peptides designated as TEP-1 (Thais excitatory peptide-1) (KCSGKWAIHACWGGN-NH2) and TEP-2 (KCYGKWAMHACWGGN-NH2) are pentadecapeptides having one disulfide bond and C-terminal GGN-NH2 structures, which are shared by most GGNG peptides. TEP augmented the motilities of Thais esophagus and penial complex. TEP-like immunoreactivity is distributed in both the neurons of the central nervous system and nerve endings in the penial complex. Thus, the involvement of TEP in the contraction of the digestive and reproductive systems is suggested. Substitution of amino acids in TEP revealed that two tryptophan residues in TEP are important for maintaining bioactivity.

収録刊行物

• Peptides

  Peptides 27 (3), 483-492, 2006-03

  Elsevier

キーワード

• HPLC
• purification
• reproduction
• imposex
• organotin

詳細情報

• CRID: 1050296265987927424
• NII論文ID: 120000878119
• NII書誌ID: AA10617807
• Web Site: http://ir.lib.hiroshima-u.ac.jp/00017114
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
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  • CiNii Articles
  • KAKEN