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Aortas from normal roosters, normal layers and hereditary restricted-ovulator hens (nonlayers) were examined electron-microscopically and biochemically. In accordance with an abnormal increase in plasma lipid levels, lipid-rich aortic lesions were more frequently observed in these nonlayers than in the layers and roosters. The three types of lipid-containing cells observed in these experimental animals originated from smooth muscle cells, fibroblast-like cells or macrophages. The malonaldehyde content was remarkably high in the plasma and aortic tissue of the nonlayers. Degenerate cells without stainable lipid, characterized by cytolysis and pyknotic nuclei, were frequently observed in the abdominal aortas of the nonlayers. These findings suggest that oxidized lipids, as well as hyperlipidmedia, may be responsible for the development of atherosclerosis in these nonlayers.


  • Acta Medica Nagasakiensia

    Acta Medica Nagasakiensia 32(1-4), 163-173, 1987-10-25


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    Departmental Bulletin Paper
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