Changes in the fluctuation of the contraction rhythm of spontaneously beating cardiac myocytes in cultures with and without cardiac fibroblasts.

• Hachiro, Takeru

• Kawahara, Koichi

• Sato, Rie

• Yamauchi, Yoshiko

• Matsuyama, Daisuke

抄録

The heart functions as a syncytium of cardiac myocytes and surrounding supportive non-myocytes such as fibroblasts. There is a possibility that a variety of non-myocyte-derived factors affect the maturation of cardiac myocytes in the development of the heart. Cultured neonatal cardiac myocytes contract spontaneously and cyclically. The fluctuation of beating rhythm varies depending on the strength of coupling through gap junctions among cardiac myocytes, indicating that the development of intercellular communication via gap junctions is crucial to the stability of contraction rhythm in cardiac myocytes. In this study, we aimed at elucidating whether and how cardiac fibroblasts affect the development of cardiac myocytes from the point of view of the changes in the fluctuation of the contraction rhythm of cardiac myocytes in cardiac myocyte-fibroblast co-cultures. The present study suggested that cardiac fibroblasts co-cultured with cardiac myocytes enhanced the intercellular communication among myocytes via gap junctions, thereby stabilizing the spontaneous contraction rhythm of cultured cardiac myocytes.

収録刊行物

• Biosystems

  Biosystems 90 (3), 707-715, 2007-11

  Elsevier

キーワード

• fluctuation of contraction rhythm
• cardiac myocytes
• cardiac fibroblasts
• gap junctions
• development

詳細情報

• CRID: 1050001338992971904
• NII論文ID: 120000951583
• HANDLE: 2115/32320
• ISSN: 03032647
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles
  • KAKEN