A different pathway in the endoplasmic reticulum stress-induced expression of human HRD1 and SEL1 genes

• Kaneko, Masayuki

• Yasui, Saori

• Niinuma, Yoshifumi

• Arai, Kiho

• Omura, Tomohiro

• Okuma, Yasunobu

• Nomura, Yasuyuki

抄録

Human HRD1 and SEL1 are components of endoplasmic reticulum-associated degradation (ERAD), which is a retrograde transport mechanism from the ER to the cytosol for removing unfolded proteins. The expression of HRD1 and SEL1 was induced by ER stress-inducing agents and overexpression of both ER stress-responsive transcription factors, ATF6 and XBP1. Inhibition of IRE1 and ATF6 revealed that ER stress-induced HRD1 and SEL1 expressions are mediated by IRE1-XBP1- and ATF6-dependent pathways, respectively. These results suggest that the ER stress-induced ERAD gene expressions are mediated by different pathways, which are attributed to the differences in the promoter regions.

収録刊行物

• FEBS Letters

  FEBS Letters 581 (28), 5355-5360, 2007-11-27

  Elsevier Science

キーワード

• HRD1
• SEL1
• ER stress
• ATF6
• XBP1
• ERAD

詳細情報

• CRID: 1050282813972003072
• NII論文ID: 120000951780
• HANDLE: 2115/32746
• ISSN: 00145793
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles