The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction

• Ohbayashi, Norihiko

• Kawakami, Shiho

• Muromoto, Ryuta

• Togi, Sumihito

• Ikeda, Osamu

• Kamitani, Shinya

• Sekine, Yuichi

• Honjoh, Tsutomu

• Matsuda, Tadashi

書誌事項

タイトル別名

• IL-6 desumoylates PML via SENP1

抄録

Post-translational modification by small ubiquitin-like modifier (SUMO) plays an important role in the regulation of different signaling pathways and is involved in the formation of promyelocytic leukemia (PML) protein nuclear bodies following sumoylation of PML. In the present study, we found that IL-6 induces desumoylation of PML and dissociation between PML and SUMO1 in hepatoma cells. We also found that IL-6 induces mRNA expression of SENP1, a member of the SUMO-specific protease family. Furthermore, wild-type SENP1 but not an inactive SENP1 mutant restored the PML-mediated suppression of STAT3 activation. These results indicate that the IL-6 family of cytokines modulates STAT3 activation by desumoylation and inactivation PML through SENP1 induction.

収録刊行物

• Biochemical and Biophysical Research Communications

  Biochemical and Biophysical Research Communications 371 (4), 823-828, 2008-07-11

  Academic Press

キーワード

• IL-6
• LIF
• SENP1
• SUMO
• STAT3
• PML
• transcriptional regulation

詳細情報

• CRID: 1050564288949783808
• NII論文ID: 120000952714
• NII書誌ID: AA00564395
• ISSN: 10902104
• ISSN: 0006291X
• HANDLE: 2115/33894
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles