KAP1 regulates type I interferon/STAT1-mediated IRF-1 gene expression

• Kamitani, Shinya

• Ohbayashi, Norihiko

• Ikeda, Osamu

• Togi, Sumihito

• Muromoto, Ryuta

• Sekine, Yuichi

• Ohta, Kazuhide

• Ishiyama, Hironobu

• Matsuda, Tadashi

Bibliographic Information

Other Title

• Interactions between STAT1 and KAP1

Abstract

Signal transducers and activators of transcription (STATs) mediate cell proliferation, differentiation, and survival in immune responses, hematopoiesis, neurogenesis, and other biological processes. Recently, we showed that KAP1 is a novel STAT-binding partner that regulates STAT3-mediated transactivation. KAP1 is a universal corepressor protein for the KRAB zinc finger protein superfamily of transcriptional repressors. In this study, we found KAP1-dependent repression of interferon (IFN) /STAT1-mediated signaling. We also demonstrated that endogenous KAP1 associates with endogenous STAT1 in vivo. Importantly, a small-interfering RNA-mediated reduction in KAP1 expression enhanced IFN-induced STAT1-dependent IRF-1 gene expression. These results indicate that KAP1 may act as an endogenous regulator of the IFN/STAT1 signaling pathway.

Journal

• Biochemical and Biophysical Research Communications

  Biochemical and Biophysical Research Communications 370 (2), 366-370, 2008-05-30

  Academic Press

Keywords

• IFN
• STAT1
• IRF-1
• KAP1
• transcriptional regulation

Details

• CRID: 1050001338996362624
• NII Article ID: 120000952715
• NII Book ID: AA00564395
• ISSN: 10902104
• ISSN: 0006291X
• HANDLE: 2115/33893
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles