A synthetic peptide from a heptad repeat region of herpesvirus glycoprotein B inhibits virus replication
Abstract
Glycoprotein B (gB) is the most conserved glycoprotein of herpesviruses and plays important roles in virus infectivity. Two intervening heptad repeat (HR) sequences were found in the C-terminal half of all herpesvirus gBs analysed. A synthetic peptide derived from the HR region (aa 477–510) of bovine herpesvirus type 1 (BoHV-1) gB was studied for its ability to inhibit virus replication. The peptide interfered with cell-to-cell spread and consistently inhibited replication of BoHV-1, with a 50 % effective concentration value (EC50) of 5 µM. Inhibition of replication was obtained not only with herpesviruses including pseudorabies virus and herpes simplex virus type 1 but also partly with Newcastle disease virus. Possible mechanisms of membrane fusion inhibition by the peptide are discussed.
Journal
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- Journal of General Virology
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Journal of General Virology 85 (8), 2131-2137, 2004
Society for General Microbiology
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Details 詳細情報について
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- CRID
- 1050001338980030464
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- NII Article ID
- 120000959442
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- ISSN
- 14652099
- 00221317
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- HANDLE
- 2115/14703
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- IRDB
- CiNii Articles