A pseudotype vesicular stomatitis virus containing Hantaan virus envelope glycoproteins G1 and G2 as an alternative to hantavirus vaccine in mice

• Lee, Byoung-Hee

• Yoshimatsu, Kumiko

• Araki, Koichi

• Okumura, Megumi

• Nakamura, Ichiro

• Arikawa, Jiro

Abstract

We examined whether a vesicular stomatitis virus (VSV) pseudotype bearing the hantavirus envelope glycoproteins (GPs) G1 and G2 (VSVÎ G*HTN) could be used as a safe and effective alternative to native hantavirus. Mice were immunized with purified particles of VSVÎ G*HTN. After the second immunization, all mice produced anti-GP antibody as detected in ELISA and a neutralization test. After the third immunization, the mice were challenged with Hantaan virus. Neither anti-NP antibody production nor Hantaan virus-specific CD8 T-cell reactions were detected in these mice. The present study demonstrated the potential of using a pseudotype VSV system as a tool for developing a hantavirus vaccine.

Journal

• Vaccine

  Vaccine 24 (15), 2928-2934, 2006-04-05

  Elsevier

Keywords

• Envelope
• Hantavirus
• Pseudotype

Details

• CRID: 1050282813950268160
• NII Article ID: 120000959673
• HANDLE: 2115/8543
• ISSN: 0264410X
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles
  • KAKEN