Suppression of tumor growth by intra-muscular transfer of naked DNA encoding adrenomedullin antagonist

• Miseki, T.

• Kawakami, H.

• Natsuizaka, M.

• Darmanin, S.

• Cui, H. Y.

• Chen, J.

• Fu, Q.

• Okada, F.

• Shindo, M.

• Higashino, F.

• Asaka, M.

• Hamuro, J.

• Kobayashi, M.

抄録

We have recently reported that the intra-tumoral injection of adrenomedullin (AM) antagonist (AMA; AM (22-52)) peptides significantly reduced the in vivo growth of a pancreatic cancer cell line in severely combined immunodeficient (SCID) mice. In the present study, we examined the effects of intra-tumoral and intra-muscular transfers of naked DNA encoding AMA on the in vivo growth of cancer cell lines. We demonstrate that these treatments induce the regression of a pancreatic cancer cell line and a breast cancer cell line inoculated in SCID mice. Furthermore, CD31-positive cells disappear completely from tumor tissues, following treatment, indicating that neo-vascularization is entirely inhibited. These results suggest that the intra-tumoral or intra-muscular transfer of naked DNA encoding AMA might be a promising alternative modality for treating human cancers.

収録刊行物

• Cancer Gene Therapy

  Cancer Gene Therapy 14 (1), 39-44, 2007-01

  Nature Publishing Group

キーワード

• hypoxia
• glucose deprivation
• adrenomedullin
• adrenomedullin antagonist
• naked DNA

詳細情報

• CRID: 1050282677904734464
• NII論文ID: 120000971212
• HANDLE: 2115/25155
• ISSN: 09291903
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles
  • KAKEN