Epstein-Barr virus-derived EBNA2 regulates STAT3 activation

• Muromoto, Ryuta

• Ikeda, Osamu

• Okabe, Kanako

• Togi, Sumihito

• Kamitani, Shinya

• Fujimuro, Masahiro

• Harada, Shizuko

• Oritani, Kenji

• Matsuda, Tadashi

書誌事項

タイトル別名

• Physical and functional interactions between STAT3 and EBNA2

抄録

The Epstein-Barr virus (EBV)-encoded latency protein EBNA2 is a nuclear transcriptional activator that is essential for EBV-induced cellular transformation. Here, we show that EBNA2 interacts with STAT3, a signal transducer for an interleukin-6 family cytokine, and enhances the transcriptional activity of STAT3 by influencing its DNA-binding activity. Furthermore, EBNA2 cooperatively acts on STAT3 activation with LMP1. These data demonstrate that EBNA2 acts as a transcriptional coactivator of STAT3.

収録刊行物

• Biochemical and Biophysical Research Communications

  Biochemical and Biophysical Research Communications 378 (3), 439-443, 2009-01-16

  Academic Press

キーワード

• STAT3
• EBV
• EBNA2
• LMP1
• LIF
• transcription

詳細情報

• CRID: 1050564288950938368
• NII論文ID: 120001024527
• NII書誌ID: AA00564395
• HANDLE: 2115/35143
• ISSN: 0006291X
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles