Effects of N-terminal fragments of β-endorphin on feeding in chicks

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Abstract

It is known that N-terminal fragments of β-endorphin have biological activities, such as an antagonism effect of β-endorphin (1–31) on the secretion of hormones or thermoregulation in mammals. We studied the effects of the N-terminal fragments on feeding behavior in male broiler chicks. Intracerebroventricular administration of β-endorphin (1–27) (0.4 nmol) stimulated feeding behavior compared with saline control during the 60-min experimental period. β-Endorphin (1–17) (2.0 nmol) also increased food intake at 30 min postinjection. Co-injection of either β-endorphin (1–27) or (1–17) was effective in reducing full-length β-endorphin-induced feeding in chicks. These data suggest that the N-terminal fragments of β-endorphin act as a partial agonist, and may regulate the activity of the central opioidergic system in chicks.

Journal

  • Neuroscience Letters

    Neuroscience Letters 442(2), 140-142, 2008-09

    Elsevier Ireland Ltd

Cited by:  1

Codes

  • NII Article ID (NAID)
    120001048960
  • NII NACSIS-CAT ID (NCID)
    AA00754925
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    0304-3940
  • Data Source
    CJPref  IR 
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