Exhaled nitric oxide levels in patients with atopic cough and cough variant asthma

• Fujimura, Masaki

• Ohkura, Noriyuki

• Abo, Miki

• Furusho, Shiho

• Waseda, Yuko

• Ichikawa, Yukari

• Hara, Johsuke

抄録

金沢大学大学院医薬保健研究域医学系

Background and objective: Atopic cough (AC) is an established clinical entity in Japan, in which patients present with a chronic persistent non-productive cough. Exhaled nitric oxide (NO) is a biomarker of eosinophilic airway inflammation. The present study examined whether exhaled NO levels were increased in AC in comparison with cough variant asthma (CVA) and bronchial asthma (BA). Methods: Consecutive patients presenting with an isolated cough lasting at least 8 weeks were enrolled in the study. The aetiology of the chronic cough was determined according to the Japanese Respiratory Society guidelines for management of cough. Exhaled NO, capsaicin cough sensitivity (capsaicin concentration eliciting five or more coughs (C5)) and bronchial reversibility were measured at the patients' first visit. Bronchial responsiveness (PC20 to methacholine) was measured at their second visit following a 6-day course of bronchodilator therapy. Results: There were 58 patients recruited and fully investigated; of these 9 and 11 patients were diagnosed with AC and CVA, respectively, as single causes of chronic cough. Ten patients with BA who had not received corticosteroid therapy in the previous 4 weeks and who attended the same clinic in the same time period acted as controls. Exhaled NO levels in patients with AC were significantly lower than those in patients with CVA and BA. There was no significant difference in the exhaled NO levels between patients with CVA and BA. Conclusions: Exhaled NO may reflect eosinophilic inflammation of peripheral airways and its measurement may be useful in differentiating CVA from AC and other causes of chronic non-productive cough. © 2008 The Authors.

収録刊行物

• Respirology

  Respirology 13 (3), 359-364, 2008-03-01

  Blackwell Publishing

キーワード

• Atopic cough
• Bronchial asthma
• Cough variant asthma
• Exhaled nitric oxide
• Non-asthmatic eosinophilic bronchitis

詳細情報

• CRID: 1050845760878303488
• NII論文ID: 120001135522
• NII書誌ID: AA11097269
• ISSN: 13237799
• Web Site: http://hdl.handle.net/2297/9771
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
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  • CiNii Articles