Phosphodiesterase 3 inhibition and cough in elderly asthmatics

• Ishiura, Yoshihisa

• Fujimura, Masaki

• Nobata, Kouichi

• Abo, Miki

• Oribe, Takayoshi

• Myou, Shigeharu

• Nakamura, Hiroyuki

抄録

金沢大学大学院医学系研究科機能再生学

Aims Cough is a common symptom of bronchial asthma, a chronic inflammatory airway disease. Recently, the therapeutic effects of selective phosphodiesterase (PDE) inhibitors have been focused on bronchial asthma. This study was designed to investigate the clinical effect of PDE 3 inhibition on cough reflex sensitivity in elderly patients with bronchial asthma. Methods Effects of cilostazol, a PDE 3 inhibitor, on cough response to inhaled capsaicin were examined in 11 patients over 70 years with stable asthma in a randomized, placebo-controlled cross over study. Capsaicin cough threshold, defined as the lowest concentration of capsaicin eliciting five or more coughs, was measured as an index of airway cough reflex sensitivity. Results The cough threshold was significantly (p < 0.05) increased after two-week treatment with cilostazol (100 mg twice a day orally) compared with placebo [48.8 (GSEM 1.4) vs. 29.2 (GSEM 1.3) μM]. Conclusion These findings indicate that PDE 3 inhibition may be a novel therapeutic option for elderly patients with asthma, especially for their cough symptoms.

収録刊行物

• Cough

  Cough 1 (11), 1-6, 2005-11-24

  BioMed Central

詳細情報

• CRID: 1050282810924886528
• NII論文ID: 120001138252
• ISSN: 17459974
• Web Site: http://hdl.handle.net/2297/7278
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles