Induction of aquaporin 1 by dexamethasone in lipid rafts in immortalized brain microvascular endothelial cells

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Abstract

Water homeostasis in the brain is essential for brain function. We have studied how###aquaporin (AQP) 1 expression in GP8 immortalized rat brain microvascular endothelial###cells is regulated by glucocorticoid. AQP1 protein level was raised by dexamethasone###treatment in a time- and concentration-dependent manner. The up-regulation of AQP1###protein by dexamethasone was associated with an increase of AQP1 mRNA level, with###no change in the degradation rate of AQP1 mRNA. AQP1 was concentrated in###detergent–insoluble fractions in the cells treated with or without dexamethasone,###suggesting that function/trafficking of AQP1 may be regulated via the interaction with###lipid rafts. Since glucocorticoid therapy has well known beneficial effects in the###treatment of brain edema, the induction of AQP1 by dexamethasone raises a possibility###that AQP1 plays a role in ameliorating brain edema.

Journal

  • Brain research : international multidisciplinary journal devoted to fundamental research in the brain sciences

    Brain research : international multidisciplinary journal devoted to fundamental research in the brain sciences 1123(1), 12-19, 2006-12-06

    Elsevier

Codes

  • NII Article ID (NAID)
    120001157598
  • NII NACSIS-CAT ID (NCID)
    AA0057324X
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    0006-8993
  • Data Source
    IR 
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