The hepatic circadian clock is preserved in a lipid-induced mouse model of non-alcoholic steatohepatitis

• Ando, Hitoshi

• Takamura, Toshinari

• Matsuzawa-Nagata, Naoto

• Shima, Kosuke R.

• Nakamura, Seiji

• Kumazaki, Masafumi

• Kurita, Seiichiro

• Misu, Hirofumi

• Togawa, Naoyuki

• Fukushima, Tatsunobu

• Fujimura, Akio

• Kaneko, Shuichi

抄録

金沢大学医薬保健研究域医学系

Recent studies have correlated metabolic diseases, such as metabolic syndrome and non-alcoholic fatty liver disease, with the circadian clock. However, whether such metabolic changes per se affect the circadian clock remains controversial. To address this, we investigated the daily mRNA expression profiles of clock genes in the liver of a dietary mouse model of non-alcoholic steatohepatitis (NASH) using a custom-made, high-precision DNA chip. C57BL/6J mice fed an atherogenic diet for 5 weeks developed hypercholesterolemia, oxidative stress, and NASH. DNA chip analyses revealed that the atherogenic diet had a great influence on the mRNA expression of a wide range of genes linked to mitochondrial energy production, redox regulation, and carbohydrate and lipid metabolism. However, the rhythmic mRNA expression of the clock genes in the liver remained intact. Most of the circadianly expressed genes also showed 24-h rhythmicity. These findings suggest that the biological clock is protected against such a metabolic derangement as NASH. © 2009 Elsevier Inc. All rights reserved.

収録刊行物

• Biochemical and Biophysical Research Communications

  Biochemical and Biophysical Research Communications 380 (3), 684-688, 2009-03-13

  Elsevier

キーワード

• Atherogenic diet
• Circadian rhythm
• Clock gene
• Non-alcoholic steatohepatitis
• Oxidative stress

詳細情報

• CRID: 1050282810930577920
• NII論文ID: 120001170074
• NII書誌ID: AA00564395
• ISSN: 0006291X
• Web Site: http://hdl.handle.net/2297/17062
• 本文言語コード: en
• 資料種別: journal article
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