Role of Angiotensin and the Clock System in the Circadian Regulation of Plasminogen Activator Inhibitor-1

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Abstract

The clock system and the renin-angiotensin system (RAS) have been reported toplay an important role in the circadian expression of plasminogen activator inhibitor-1(PAI-1) gene. However, the degree of involvement of these systems remains unknown.In the present study, we investigated the roles of the clock system and the RAS in thecircadian expression of PAI-1 in the peripheral tissues in vivo by using Cry1/Cry2double knockout (Cry1/2-deficient) and angiotensin type 1 (AT1a) receptor knockout(AT1a-deficient) mice. We observed no significant rhythmicity in the PAI-1 expressionin all tissues examined in Cry1/2-deficient mice; this suggests that the clock system isindispensable for the circadian expression of PAI-1. In AT1a-deficient mice, apparentcircadian oscillation of PAI-1 expression was observed in the lung and liver but not in the kidney, suggesting that AT1a-mediated signaling modulates the circadianexpression of PAI-1 in a tissue-specific manner.

Journal

  • The Kobe journal of the medical sciences

    The Kobe journal of the medical sciences 54(6), 264-271, 2008-12

    神戸大学医学部

Codes

  • NII Article ID (NAID)
    120001478900
  • NII NACSIS-CAT ID (NCID)
    AA00711740
  • Text Lang
    ENG
  • Article Type
    departmental bulletin paper
  • ISSN
    0023-2513
  • Data Source
    IR 
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