Reproducibility of semi-quantitative parameters in FDG-PET using two different PET scanners: Influence of attenuation correction method and examination interval
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Purpose: To evaluate the reproducibility of semi-quantitative parameters obtained from two FDG-PET studies using two different PET scanners. Methods: Forty-five patients underwent FDG-PET examination with two different PET scanners on separate days. Two PET images with different attenuation correction method were generated in each patient and three ROIs were placed on the lung tumor and normal organs (mediastinum and liver) in each image. Mean and maximum SUVs, tumor-to-mediastinum and tumor-to-liver ratios (T/M and T/L) and the percentage difference in parameters between 2 PET images (% Diff.) were compared. Results: All measured values except maximum SUV in the liver and tumor-related parameters (SUV in lung tumor, T/M, T/L) showed no significant difference between 2 PET images. Conclusion: The mean measured values showed high reproducibility and demonstrate that follow-up study or measurement of tumor response to anticancer drugs can be undertaken by FDG-PET examination without specifying the particular type of PET scanner.
- MOLECULAR IMAGING AND BIOLOGY
MOLECULAR IMAGING AND BIOLOGY 10(3), 162-166, 2008-05