Replacement of cisplatin with nedaplatin in a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma

• Kuwahara, Akiko

• Yamamori, Motohiro

• Nishiguchi, Kohshi

• Okuno, Tatsuya

• Chayahara, Naoko

• Miki, Ikuya

• Tamura, Takao

• Inokuma, Tsubasa

• Takemoto, Yoshiji

• Nakamura, Tsutomu

• Kataoka, Kazusaburo

• Sakaeda, Toshiyuki

Abstract

Objective: The effects of replacing cisplatin (CDDP) with cis-diammineglycolatoplatinum (nedaplatin, NDP), a second-generation platinum complex, on the pharmacokinetics of 5-fluorouracil (5-FU) were investigated in Japanese patients with esophageal squamous cell carcinoma, who were treated with a definitive 5-FU/CDDP-based chemoradiotherapy. Methods: Fifty-six patients were enrolled, 49 treated with CDDP and 7 treated with NDP. A course consisted of continuous infusion of 5-FU at 400 mg/m²/day for days 1-5 and 8-12, infusion of CDDP or NDP at 40 mg/m²/day on days 1 and 8, and radiation at 2 Gy/day on days 1 to 5, 8 to 12, and 15 to 19, with a second course repeated after a 2-week interval. Plasma concentrations of 5-FU were determined by high performance liquid chromatography at 5 PM on days 3, 10, 38 and45, and at 5 AM on days 4, 11, 39 and 46. Results and conclusions: The circadian rhythm in plasma concentrations of 5-FU observed in the case of CDDP was altered when NDP was used instead. The clinical response can be predicted by monitoring plasma concentrations of 5-FU in the CDDP group, but not in the NDP group.

Journal

• International Journal of Medical Sciences

  International Journal of Medical Sciences 6 (6), 305-311, 2009-06

  Ivyspring International Publisher

Keywords

• 5-fluorouracil
• Chemoradiotherapy
• Esophageal squamous cell carcinoma
• Nedaplatin
• Plasma concentration

Details

• CRID: 1050001201938609920
• NII Article ID: 120001887679
• ISSN: 14491907
• HANDLE: 2433/97922
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles