Synthesis of 3,3-disubstituted oxindoles through Pd-catalyzed intramolecular cyanoamidation

• 竹本, 佳司

• Kamisaki, Haruhi

• Ishida, Takayuki

• Takemoto, Yoshiji

抄録

The cyanoamidation of olefins was achieved. When N-(2-vinylphenyl)cyanoformamides were treated with palladium catalyst, intramolecular cyanoamidation took place to give corresponding 3, 3-disubstituted oxindoles. P(t-Bu)3 showed a remarkable effect on this reaction. When it was used with Pd(dba)2, the reaction was completed in 15 min at 100 oC for many substrates. Furthermore, the enantioselective cyanoamidation was accomplished with Pd(dba)2 and an optically active phosphoramidite to provide optically active 3, 3-disubstituted oxindoles. Manipulation of the resulting oxindoles has been studied.

収録刊行物

• Tetrahedron

  Tetrahedron 66 (11), 1980-1989, 2010-03-13

  Elsevier

詳細情報

• CRID: 1050282677040580224
• NII論文ID: 120001923313
• ISSN: 00404020
• HANDLE: 2433/101563
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles
  • KAKEN