Associations between glutathione S-transferase pi Ile105Val and glyoxylate aminotransferase Pro11Leu and Ile340Met polymorphisms and early-onset oxaliplatin-induced neuropathy.

• 金井, 雅史

• Yoshioka, Akira

• Tanaka, Shiro

• Nagayama, Satoshi

• Matsumoto, Shigemi

• Nishimura, Takafumi

• Niimi, Miyuki

• Teramukai, Satoshi

• Takahashi, Ryo

• Mori, Yukiko

• Kitano, Toshiyuki

• Ishiguro, Hiroshi

• Yanagihara, Kazuhiro

• Chiba, Tsutomu

• Fukushima, Masanori

• Matsuda, Fumihiko

抄録

PURPOSE: Although the risk of oxaliplatin-induced neuropathy depends on cumulative oxaliplatin dose, susceptibility to this adverse event differs greatly among patients. In this study, we investigated the associations between oxaliplatin-induced neuropathy and the following polymorphisms: glutathione S-transferase pi (GSTP1) Ile(105)Val, and glyoxylate aminotransferase (AGXT) Pro(11)Leu and AGXT Ile(340)Met. EXPERIMENTAL DESIGN: Eighty-two Japanese patients with histologically confirmed colorectal cancer who received at least six cycles of the modified FOLFOX6 (m-FOLFOX6) regimen were enrolled. To minimize differences in cumulative oxaliplatin dose between patients, oxaliplatin-induced neuropathy was evaluated using an oxaliplatin-specific scale during the 2-week period after completion of the sixth cycle of treatment. RESULTS: Forty-four patients developed grade 2/3 oxaliplatin-induced neuropathy. There were more patients carrying at least one GSTP1(105)Val allele among the group with grade 2/3 neuropathy (18/44, 41%) than among the group with grade 1 neuropathy (9/38, 24%), although the difference was not statistically significant (P=0.098). There were similar numbers of patients carrying at least one AGXT(105)Met allele in the grade 2/3 neuropathy (7/44, 16%) and grade 1 neuropathy groups (5/38, 13%; P=0.725). The AGXT(11)Leu allele was not found in any of our patients or controls. CONCLUSIONS: We found no significant association between oxaliplatin-induced neuropathy and the GSTP1 Ile(105)Val and AGXT Ile(340)Met polymorphisms. Given that no AGXT(11)Leu allele was found among our study population (n=177), evaluating this polymorphism in Japanese patients in future studies is likely to be uninformative.

収録刊行物

• Cancer epidemiology

  Cancer epidemiology 34 (2), 189-193, 2010-04

キーワード

• Oxaliplatin
• Neurotoxicity
• Colorectal cancer
• GSTP1 Ile105Val
• AGXT Pro11Leu
• AGXT Ile340Met

詳細情報

• CRID: 1050001202176981760
• NII論文ID: 120002098847
• NII書誌ID: AA12419531
• ISSN: 18777821
• HANDLE: 2433/109963
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles