Possible involvement of T helper type 2 responses to Toll-like receptor ligands in IgG4-related sclerosing disease.

• 渡邉, 智裕

• Watanabe, Tomohiro

• Zaima, Chikage

• Uza, Norimitsu

• Ida, Hiroshi

• Tada, Shinsuke

• Nishida, Naoshi

• Chiba, Tsutomu

抄録

We report a case of immunoglobulin G4 (IgG4)-related sclerosing disease involving the pancreas, liver and salivary glands. Massive infiltration of IgG4-expressing plasma cells was seen in the liver and submandibular lymph nodes. Interestingly, accumulation of IgG4-expressing plasma cells was also seen in the colon and terminal ileum. Peripheral blood mononuclear cells (PBMCs) isolated from this patient exhibited enhanced production of IgG4 and interleukin-10 upon stimulation with Toll-like receptor (TLR) ligands as compared with those from a healthy control. In contrast, production of tumour necrosis factor alpha and interferon gamma by PBMCs from this patient was markedly reduced. Since colonic mucosa is always exposed to TLR ligands derived from commensal organisms, the results of immunological studies suggest that enhanced T helper type 2 responses to intestinal microflora may underlie the immunopathogenesis in this patient with IgG4-related sclerosing disease.

収録刊行物

• Gut

  Gut 59 (4), 542-545, 2010-04

  BMJ Publishing Group Ltd & British Society of Gastroenterology

キーワード

• Aged
• Autoimmune Diseases/immunology
• Cells, Cultured
• Cholangitis, Sclerosing/immunology
• Humans
• Immunoglobulin G/metabolism
• Ligands
• Male
• Pancreatitis/immunology
• Th2 Cells/immunology
• Toll-Like Receptors

詳細情報

• CRID: 1050282677154335488
• NII論文ID: 120002191881
• NII書誌ID: AA00660592
• ISSN: 00175749
• HANDLE: 2433/120797
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles