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The hypothalamic suprachiasmatic nucleus (SCN) has a pivotal role in the mammalian circadian clock. SCN neurons generate circadian rhythms in action potential firing frequencies and neurotransmitter release, and the core oscillation is thought to be driven by "clock gene" transcription-translation feedback loops. Cytosolic Ca2+ mobilization followed by stimulation of various receptors has been shown to reset the gene transcription cycles in SCN neurons, whereas contribution of steady-state cytosolic Ca2+ levels to the rhythm generation is unclear. Recently, circadian rhythms in cytosolic Ca2+ levels have been demonstrated in cultured SCN neurons. The circadian Ca2+ rhythms are driven by the release of Ca2+ from ryanodine-sensitive internal stores and resistant to the blockade of action potentials. These results raise the possibility that gene translation/transcription loops may interact with autonomous Ca2+ oscillations in the production of circadian rhythms in SCN neurons.
Article
Neuroscientist
収録刊行物
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- The neuroscientist : a review journal bridging neurobiology, neurology and psychiatry
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The neuroscientist : a review journal bridging neurobiology, neurology and psychiatry 10 (4), 315-324, 2004-08
Sage
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詳細情報 詳細情報について
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- CRID
- 1050001339101240832
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- NII論文ID
- 120002224950
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- NII書誌ID
- AA1105543X
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- ISSN
- 10738584
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- HANDLE
- 10110/88
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- IRDB
- CiNii Articles