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Abstract

The small GTPase ADP-ribosylation factor 6 (ARF6) plays crucial roles in a wide variety of cell functions. To better understand the molecular mechanisms of ARF6-mediated signaling and cellular functions, we sought new ARF6-binding proteins in the mouse brain. We identified the signaling scaffold protein JNK-interacting protein 3 (JIP3), which is exclusively expressed in neurons, as a downstream effector of ARF6. Overexpression of a unique dominant negative mutant of ARF6, which was unable to interact with JIP3, and knockdown of JIP3 in mouse cortical neurons stimulated the elongation and branching of neurites. These results provide evidence that ARF6/JIP3 signaling regulates neurite morphogenesis.

Journal

  • FEBS letters

    FEBS letters 584(13), 2801-2806, 2010-07

    Elsevier B.V.

Keywords

Codes

  • NII Article ID (NAID)
    120002233499
  • NII NACSIS-CAT ID (NCID)
    AA00642943
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    0014-5793
  • Data Source
    IR 
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