Pathophysiological Classification of Functional Dyspepsia Using a Novel Drinking-Ultrasonography Test

• Kato, Mototsugu

• Nishida, Urara

• Nishida, Mutsumi

• Hata, Tamotsu

• Asaka, Rumiko

• Haneda, Masahira

• Yamamoto, Keiko

• Imai, Aki

• Yoshida, Takeshi

• Ono, Shouko

• Shimizu, Yuichi

• Asaka, Masahiro

Abstract

Background: Functional dyspepsia (FD) is a heterogeneous disease characterized by various upper abdominal symptoms. The major mechanism of FD symptoms includes impaired fundic accommodation, delayed gastric emptying, and visceral hypersensitivity. We developed a novel drinking-ultrasonography to combine a drink test with ultrasonography to assess gastric motility and sensory function of FD patients. Method: Subjects were sixty successive FD patients according to the Rome III criteria. A drinking-ultrasonography test was performed after subjects had fasted. The subjects ingested 200 ml of water at two-minute intervals four times (total 800 ml) through a straw. The maximum cross-section of the proximal stomach was visualized before water intake, after each water intake, and 5 and 10 minutes after the completion of drinking using extracorporeal ultrasonography. Abdominal symptoms were evaluated using the visual analog scale (VAS) a total of 5 times. Normal range of cross-sectional area and VAS were set using average ±2 standard deviations of 33 healthy volunteers. Cases outside the normal range were diagnosed with a motor or sensory disorder. Results: The drinking-ultrasonography test classified FD patients into four groups without adverse effect or trouble. The distribution of each group was 27% in the normal group, 15% in the impaired relaxation group, 10% in the delayed emptying group, and 48% in the visceral hypersensitivity group. There was no significant correlation between the pathophysiological classification and subtypes of FD defined by the Rome III criteria. Conclusion: We developed a novel drinking-ultrasonography test that was effective in classifying FD patients according to pathophysiological features.

Journal

• Digestion

  Digestion 82 (3), 162-166, 2010-06

  Karger

Keywords

• Functional gastroduodenal disorders
• Drink test
• Visceral hypersensitivity
• Gastric emptying
• Gastric relaxation

Details

• CRID: 1050845763936028800
• NII Article ID: 120002248667
• HANDLE: 2115/43267
• ISSN: 00122823
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles