On the func­tion of the Megakaryocyte (Motility, Separation of the Platelet and Phagocytosis), Observations Both in Idiopathic Thrombo-cytopenic Purpura and in Normal Adult

Access this Article

Search this Article


<p>The idiopathic thrombocytopenic purpura was described byWerlhof as an independent disease first in 1738. Kaznelsonreported the excellent effect of splenectomy for its chronic type in 1915. For the genesis of its thrombocytopenia, there have been many theories to be concluded into the followings, 1) the development of an auto-immune mechanism resulting in platelet destruction, 2) increased platelet destruction in the spleen, 3)the inhibition of platelet production from the marrow megakaryocytes by a humoral factor produced in the spleen, 4) both increased destruction and decreased production of the platelet. Among the above four theories, the third one is the most popular in the chronic type.</p>


  • Acta Medicinae Okayama

    Acta Medicinae Okayama 10(2), 57-61, 1956-04

    Okayama University Medical School


Page Top