慢性関節リウマチ患者の血清および関節液中のフェリチンの測定について  [in Japanese] Determination of ferritin in serum and in synovial fluids of patients with rheumatoid arthritis  [in Japanese]

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Abstract

Ferritin in sera and in synovial fluids were determined by method of immunoradiometric assay (IRMA) and of radioimmunoassay (RIA). These methods have been proved to be reproducible. The coefficient variation was 7.4 to 9.9% in IRMA and 5.6 to 8.0% in RIA. There were a good correlation between methods of IRMA and of RIA (r=0.989). The mean recovery rate of ferritin in serum was 101.2% in IRMA and 101.0% in RIA, respectively. The determination of serum ferritin revealed a 16% reduction in average after preservation at -20℃ during over 100 days. The levels of serum ferritin in healthy controls were 131.4±52.1 ng/ml in 34 males and 58.4±39.9 ng/ml in 38 females. The sex differences were statisticalIy significant (p<0.01). Ferritin levels were shown to be below 30 ng/ml (the state of iron deficiency) in 2 of 34 (5.9%) males and in 8 of 38 (21%) females of healthy controls. The levels of serum ferritin in patients with rheumatoid arthritis (RA) were 337.0±293.4ng/ml in 10 males and 181.4±329.9ng/ml in 25 females. The serum ferritin in RA was significantly higher than in healthy controls of both sexes. The levels of ferritin in synovial fluids of patients with 14 RA and with 12 osteoarthritis were 2894±3017 ng/ml and 1429±1005 ng/ml, and no differences were observed in both groups.

Journal

  • Papers of the Institute for Thermal Spring Research,Okayama University

    Papers of the Institute for Thermal Spring Research,Okayama University (53), p1-8, 1983-03

    岡山大学温泉研究所

Codes

  • NII Article ID (NAID)
    120002311016
  • NII NACSIS-CAT ID (NCID)
    AN00032853
  • Text Lang
    JPN
  • Article Type
    departmental bulletin paper
  • Journal Type
    大学紀要
  • ISSN
    03697142
  • NDL Article ID
    2625601
  • NDL Source Classification
    SC261;SC551
  • NDL Source Classification
    ZS47(科学技術--医学--治療医学・看護学・漢方医学)
  • NDL Call No.
    Z19-268
  • Data Source
    NDL  IR 
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