アルキン型リンカーを用いた糖鎖固相合成--薗頭反応による高反応部位の選択
書誌事項
- タイトル別名
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- Solid-phase Synthesis of Oligosaccharides Using Novel Alkyne-type Linkers -Selection of Reactive Sites on the support by Sonogashira Reaction-
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抄録
Two new alkyne-type linkers having alkynylmethyloxy moieties were elaborated for solid-phase synthesis of oligosaccharide. A propargyl glycoside-type linker between a sugar residue and a solid support was formed by the Sonogashira reaction of a propargyl glycoside with polymer-supported iodobenzene. A propargyl ester-type linker was also constructed by the same reaction of a 4-(proparygyloxycarbonyl)benzyl glycoside with the latter. Both linkers are stable against acids such as TFA but can be readily cleaved with this acid after conversion to the corresponding alkyne-cobalt complex by treatment with Co2(CO)8. The latter ester linker is generally advantageous in that mild cleavage liberates a proceed only at spatially reactive sites on the solid support where the reagent accesses readily, so that the subsequent reactions including glycosylation on solid phase proceeded smoothly to result in high total yields of the desired oligosaccharides.
収録刊行物
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- 岡山大学農学部学術報告
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岡山大学農学部学術報告 94 (1), 81-84, 2005-02-01
岡山大学農学部
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詳細情報 詳細情報について
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- CRID
- 1050002212334277248
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- NII論文ID
- 120002311209
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- NII書誌ID
- AN00033029
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- ISSN
- 04740254
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- 本文言語コード
- ja
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- 資料種別
- departmental bulletin paper
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- データソース種別
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- IRDB
- CiNii Articles